Chemoradiation Morbidity in Carcinoma Cervix and Hematologic Toxicity: A South Indian Prospective Study

Chemoradiation is the current standard of care in patients with locally advanced carcinoma cervix. Although extensive literature is available on the acute morbidity due to chemoradiotherapy in women with cancer cervix, most of the studies have been done at carefully prepared academic centers in developed countries (Rose et al., 1999; Maduro et al., 2003; Ikushima et al., 2006; Mahantshetty et al., 2010; Khalid et al., 2012). Socially disadvantaged women in less developed countries of the world may be more susceptible to the combined treatment’s toxic effects due to poor nutritional status, presence of comorbid chronic conditions and of difficulties in accessing medical care during treatment. In this study we analyzed the chemoradiation induced acute morbidity in women with cancer cervix in our set up using the latest National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4 scoring system (NCI, NIH publication 2009). The objectives of this study were to assess the chemoradiation related acute morbidity in women of South Indian ethnicity with carcinoma cervix and to see if there